Dr. Pascal Giehr - Faculty for Chemistry and Pharmacy
Dr. Pascal Giehr - Faculty for Chemistry and Pharmacy
Our lab investigates how distinct epigenetic and epitranscriptomic factors influence chromatin architecture, genome stability, and gene regulation. We are particularly focused on dynamic nucleic acid modifications (NAMs) in both DNA and RNA.
Our goal is to uncover the molecular mechanisms driving these dynamic changes, which are fundamental to cell physiology, particularly in shaping cell identity and function during development and disease. To achieve this, we employ cutting-edge next- and third-generation sequencing technologies and develop innovative laboratory and computational tools to study epigenetic and epitranscriptomic modifications at the single-molecule level.
By decoding these molecular pathways, we aim to lay the groundwork for novel therapeutic strategies and new approaches to cellular (re)programming and (trans)differentiation.