Dr. Pascal Giehr - Faculty for Chemistry and Pharmacy
Dr. Pascal Giehr - Faculty for Chemistry and Pharmacy
Sahin, H., Islam, S., Lee, A. H., Ponzo, I., Reichl, A., Carell, T., & Giehr, P. (2025). Biochemical engineering of 5hmdC-DNA using a Tet3 double-mutant. bioRxiv, 2025-06.
Kavle, R. R., Henzeler, B., Faya, N., Giehr, P., Bekhit, A. E. D. A., Carne, A., ... & Agyei, D. (2025). Deciphering Huhu (Prionoplus reticularis) grub development: Transcriptomic insights into metabolic and nutritional shifts in larval stages
Riquelme-Barrios, S., Vásquez-Camus, L., Cusack, S. A., Burdack, K., Petrov, D. P., Yeşiltaç-Tosun, G. N., ... Giehr, P. & Jung, K. (2025). Direct RNA sequencing of the Escherichia coli epitranscriptome uncovers alterations under heat stress. Nucleic Acids Research, 53(6), gkaf175.
Sahin, H., Salehi, R., Islam, S., Müller, M., Giehr, P., & Carell, T. (2024). Robuste Bisulfit‐freie Einzelmolekül‐Echtzeitsequenzierung von Methyldesoxycytidin auf der Grundlage eines neuartigen hpTet3‐Enzyms. Angewandte Chemie, 136(52), e202418500.
Sadafi, A., Salehi, R., Gruber, A., Boushehri, S. S., Giehr, P., Navab, N., & Marr, C. (2023, October). A continual learning approach for cross-domain white blood cell classification. In MICCAI Workshop on Domain Adaptation and Representation Transfer (pp. 136-146). Cham: Springer Nature Switzerland.
Kyriakopoulos, C., Nordström, K., Kramer, P. L., Gottfreund, J. Y., Salhab, A., Arand, J., ... & Giehr, P. (2022). A comprehensive approach for genome-wide efficiency profiling of DNA modifying enzymes. Cell reports methods, 2(3), 100187.
Haggerty, C., Kretzmer, H., Riemenschneider, C., Kumar, A. S., Mattei, A. L., Bailly, N., Gottfreund, J., Giesselmann, P., Weigert, R., Brändl, B., Giehr, P., ... & Meissner, A. (2021). Dnmt1 has de novo activity targeted to transposable elements. Nature Structural & Molecular Biology, 28(7), 594-603.
Kyriakopoulos, C., Giehr, P., Lück, A., Walter, J., & Wolf, V. (2019, April). A hybrid HMM approach for the dynamics of DNA methylation. In International Workshop on Hybrid Systems Biology (pp. 117-131). Springer, Cham.
Lück, A., Giehr, P., Nordström, K., Walter, J., & Wolf, V. (2019). Hidden Markov modelling reveals neighborhood dependence of Dnmt3a and 3b activity. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 16(5), 1598-1609.
Giehr, P., & Walter, J. (2018). Hairpin bisulfite sequencing: synchronous methylation analysis on complementary DNA strands of individual chromosomes. In DNA Methylation Protocols (pp. 573-586). Humana Press, New York, NY.
Jafari, N., Giehr, P., Hesaraki, M., Baas, R., de Graaf, P., Timmers, H. M., ... & Totonchi, M. (2018). Genomic integrity of ground‐state pluripotency. Journal of Cellular Biochemistry, 119(12), 9781-9789.
Giehr, P., Kyriakopoulos, C., Lepikhov, K., Wallner, S., Wolf, V., & Walter, J. (2018). Two are better than one: HPoxBS-hairpin oxidative bisulfite sequencing. Nucleic acids research, 46(15), e88-e88.
Nowak, A., Lock, D., Bacher, P., Hohnstein, T., Vogt, K., Gottfreund, J., Giehr, P., ... & Scheffold, A. (2018). CD137+ CD154− expression as a regulatory T cell (Treg)-specific activation signature for identification and sorting of stable human tregs from in vitro expansion cultures. Frontiers in immunology, 9, 199.
Lück, A., Giehr, P., Walter, J., & Wolf, V. (2017, September). A stochastic model for the formation of spatial methylation patterns. In International Conference on Computational Methods in Systems Biology (pp. 160-178). Springer, Cham.
Lan, J., Lepikhov, K., Giehr, P., & Walter, J. (2017). Histone and DNA methylation control by H3 serine 10/threonine 11 phosphorylation in the mouse zygote. Epigenetics & chromatin, 10(1), 1-19.
Kyriakopoulos, C., Giehr, P., & Wolf, V. (2016). H (O) TA: estimation of DNA methylation and hydroxylation levels and efficiencies from time course data. arXiv preprint arXiv:1606.07807.
Eckersley-Maslin, M. A., Svensson, V., Krueger, C., Stubbs, T. M., Giehr, P., Krueger, F., ... & Reik, W. (2016). MERVL/Zscan4 network activation results in transient genome-wide DNA demethylation of mESCs. Cell reports, 17(1), 179-192.
Giehr, P., Kyriakopoulos, C., Ficz, G., Wolf, V., & Walter, J. (2016). The influence of hydroxylation on maintaining CpG methylation patterns: a hidden Markov model approach. PLoS computational biology, 12(5), e1004905.
Toker, A., Engelbert, D., Garg, G., Polansky, J. K., Floess, S., Miyao, T., Baron, U., Düber, S., Geffers, R., Giehr, P., ... & Huehn, J. (2013). Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus. The Journal of Immunology, 190(7), 3180-3188.